Document Detail

Reactive oxygen species and endothelial function in diabetes.
MedLine Citation:
PMID:  20371238     Owner:  NLM     Status:  MEDLINE    
An increasing body of evidence suggests that oxidant stress is involved in the pathogenesis of many cardiovascular diseases, including hypercholesterolemia, atherosclerosis, hypertension, heart failure and diabetes. Recent studies have also provided important new insights into potential mechanisms underlying the pathogenesis of vascular disease induced by diabetes. Glycosylation of proteins and lipids, which can interfere with their normal function, activation of protein kinase C with subsequent alteration in growth factor expression, promotion of inflammation through the induction of cytokine secretion and hyperglycemia-induced oxidative stress are some of these mechanisms. It is widely accepted that hyperglycemia-induced reactive oxygen species contribute to cell and tissue dysfunction in diabetes. A variety of enzymatic and non-enzymatic sources of reactive oxygen species exist in the blood vessels. These include NADPH oxidase, mitochondrial electron transport chain, xanthine oxidase and nitric oxide synthase. The present article reviews the effects of reactive oxygen species on endothelial function in diabetes and addresses possible therapeutic interventions.
Zahra Fatehi-Hassanabad; Catherine B Chan; Brian L Furman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-02
Journal Detail:
Title:  European journal of pharmacology     Volume:  636     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  8-17     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier B.V. All rights reserved.
Department of Physiology, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Diabetes Mellitus / metabolism*,  pathology*
Endothelial Cells / metabolism*,  pathology
Endothelium, Vascular / metabolism,  pathology
Reactive Nitrogen Species / metabolism
Reactive Oxygen Species / metabolism*
Grant Support
MOP 43978//Canadian Institutes of Health Research
Reg. No./Substance:
0/Reactive Nitrogen Species; 0/Reactive Oxygen Species

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