| Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation. | |
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MedLine Citation:
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PMID: 21318733 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE AND DESIGN: To clarify the molecular mechanism of polyenylphosphatidylcholine (PPC), we examined the involvement of reactive oxygen species (ROS) and NADPH oxidase 4 (Nox4) in human hepatic stellate cells (HSCs). MATERIAL: Using human LX-2 HSC cells, we examined the effects of PPC on expression of α-smooth muscle actin (α-SMA) and collagen 1, generation of ROS, Nox4 expression, p38 activation and cell proliferation, induced by transforming growth factor β1 (TGFβ1). RESULTS: PPC suppressed ROS which are induced by TGFβ1, phosphorylation of p38MAPK, and expression levels of α-SMA and collagen 1 in a dose-dependent manner. Higher concentrations of PPC also suppressed Nox4 levels. CONCLUSION: These results suggest that ROS and Nox4 induced by TGFβ1 are the therapeutic targets of PPC in the suppression of human hepatic stellate cell activation. |
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Authors:
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Remina Ikeda; Kyoko Ishii; Yoshiko Hoshikawa; Junya Azumi; Yuta Arakaki; Toshihiro Yasui; Shizuka Matsuura; Yoshiaki Matsumi; Yohei Kono; Yusuke Mizuta; Akihiro Kurimasa; Ichiro Hisatome; Scott L Friedman; Hironaka Kawasaki; Goshi Shiota |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-13 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: - ISSN: 1420-908X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, 683-8504, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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