| Reactive oxygen metabolites: a link between oxidative stress and inflammation in patients on hemodialysis. | |
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MedLine Citation:
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PMID: 17215574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress plays a significant role in the development of inflammation in patients undergoing hemodialysis (HD). This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress. Plasma total antioxidant capacity (TAC), lipid peroxidation products malonaldehyde (MDA) and 4-hydroxyalkenals, as well as d-ROMs, were determined in 24 patients before HD and in 21 normal controls (NC). It was found that HD patients had higher levels of d-ROMs than NC (p = 0.033). A highly significant positive correlation was observed between logCRP and d-ROMs concentrations (p < 0.0001, r = 0.85) in patients, but not in NC. The concentrations of TAC and MDA were not associated with CRP in HD or in NC individuals. It is concluded that d-ROMs concentration is a potent marker of oxidative injury that is strongly indicative of the inflammatory status in HD patients. |
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Authors:
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E Samouilidou; E Grapsa; A Karpouza; A Lagouranis |
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Publication Detail:
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Type: Journal Article Date: 2007-01-11 |
Journal Detail:
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Title: Blood purification Volume: 25 ISSN: 1421-9735 ISO Abbreviation: Blood Purif. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-21 Completed Date: 2007-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
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Languages: eng Pagination: 175-8 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Biochemical Department, Alexandra Hospital, Athens, Greece. tkk@otenet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldehydes / blood Antioxidants / metabolism C-Reactive Protein / metabolism Female Humans Inflammation / etiology* Lipid Peroxides / blood Male Malondialdehyde / blood Middle Aged Oxidative Stress / physiology* Reactive Oxygen Species / metabolism* Renal Dialysis / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Antioxidants; 0/Lipid Peroxides; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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