Document Detail

Reactive oxygen metabolites: a link between oxidative stress and inflammation in patients on hemodialysis.
MedLine Citation:
PMID:  17215574     Owner:  NLM     Status:  MEDLINE    
Oxidative stress plays a significant role in the development of inflammation in patients undergoing hemodialysis (HD). This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress. Plasma total antioxidant capacity (TAC), lipid peroxidation products malonaldehyde (MDA) and 4-hydroxyalkenals, as well as d-ROMs, were determined in 24 patients before HD and in 21 normal controls (NC). It was found that HD patients had higher levels of d-ROMs than NC (p = 0.033). A highly significant positive correlation was observed between logCRP and d-ROMs concentrations (p < 0.0001, r = 0.85) in patients, but not in NC. The concentrations of TAC and MDA were not associated with CRP in HD or in NC individuals. It is concluded that d-ROMs concentration is a potent marker of oxidative injury that is strongly indicative of the inflammatory status in HD patients.
E Samouilidou; E Grapsa; A Karpouza; A Lagouranis
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Publication Detail:
Type:  Journal Article     Date:  2007-01-11
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Biochemical Department, Alexandra Hospital, Athens, Greece.
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MeSH Terms
Aldehydes / blood
Antioxidants / metabolism
C-Reactive Protein / metabolism
Inflammation / etiology*
Lipid Peroxides / blood
Malondialdehyde / blood
Middle Aged
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism*
Renal Dialysis / adverse effects*
Reg. No./Substance:
0/Aldehydes; 0/Antioxidants; 0/Lipid Peroxides; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde; 9007-41-4/C-Reactive Protein

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