Document Detail

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease.
MedLine Citation:
PMID:  2400911     Owner:  NLM     Status:  MEDLINE    
Expression of major histocompatibility complex (MHC) class I (HLA-A,B,C) and class II (HLA-DR) antigens was studied in postmortem brain tissue of Alzheimer's disease and age-matched control cases. Monoclonal antibodies to class I antigens stained reactive microglia weakly to moderately and vascular endothelial cells strongly in Alzheimer's gray and white matter. Capillaries were also stained strongly in control brains, but only a few positively stained microglia could be observed in white matter. In Alzheimer cases, HLA-DR positive reactive microglia were more numerous and more strongly staining than MHC class I positive reactive microglia but many cells appeared to express both classes of antigen. Rare large cells of uncertain origin also stained positively for class I. Double immunostaining established that MHC class I positive cells were a separate population from glial fibrillary acidic-protein-positive astrocytes.
I Tooyama; H Kimura; H Akiyama; P L McGeer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  523     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-23     Completed Date:  1990-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
Molecular Biology Research Centre, Shiga University of Medical Science, Otsu, Japan.
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MeSH Terms
Antibodies, Monoclonal
Brain / immunology*,  pathology
Cell Aggregation
HLA-A Antigens / analysis
HLA-B Antigens / analysis
HLA-C Antigens / analysis
HLA-DR Antigens / analysis
Histocompatibility Antigens Class I / analysis*
Histocompatibility Antigens Class II / analysis
Reference Values
Temporal Lobe / immunology*,  pathology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens; 0/HLA-DR Antigens; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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