Document Detail

Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis.
MedLine Citation:
PMID:  20581780     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although reactive lymphoid hyperplasia (RLH) can be found in various organs, including the gastrointestinal tract, orbit, lung, and skin, its occurrence in the liver is rare.
CASE REPORT: We report the case of a 47-year-old RLH woman who was identified with RLH of the liver during clinical follow- up of primary biliary cirrhosis. The mass, found incidentally during a medical examination, appeared on ultrasonogram as a hypoechoic mass in the 7th segment of the liver. Further analyses using composed tomography, magnetic resonance imaging, and angiography suggested malignancy, and we performed lateral segmentectomy of the liver. Histologically, the tumor was composed of lymphoid follicles with germinal centers that expressed kappa and lambda light-chain B-cell markers at equal frequency, and no IgH gene rearrangements were detected in Southern blots. Based on these results, we identified the lesion as RLH.
CONCLUSIONS: We suggest that this diagnosis be taken into consideration in other cases involving a space-occupying liver mass associated with autoimmune disease.
Yuka Fukuo; Tomoyoshi Shibuya; Yuki Fukumura; Tomokazu Mizui; Jin Kan Sai; Akihito Nagahara; Akira Tsukada; Toshiharu Matsumoto; Masafumi Suyama; Sumio Watanabe
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-21     Revised Date:  2011-06-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CS81-6     Citation Subset:  IM    
Department of Gastroenterology Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
Liver / pathology*,  radiography,  surgery
Liver Cirrhosis, Biliary / complications*,  pathology,  radiography,  surgery
Middle Aged
Pseudolymphoma / complications*,  pathology,  radiography,  surgery
Tomography, X-Ray Computed

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