Document Detail

Reactive hyperemia in term neonates and adults--a laser Doppler fluxmetry study of skin microcirculation.
MedLine Citation:
PMID:  1828856     Owner:  NLM     Status:  MEDLINE    
The reactivities of neonatal and adult microcirculation have been studied and compared. The cutaneous reactive hyperemia after 1 and 4 min of arterial occlusion (AO) was measured with a laser-Doppler fluxmeter in 21 healthy neonates and 10 adults. Local skin temperature, mean arterial blood pressure (MAP), and skin prick hematocrit were also determined at the same time. The magnitude of neonatal reactive hyperemia was approximately one-third that of the adult response regardless of the duration of AO. In both groups, with age-specific regressions, the hyperemic blood flow response after 4 min of AO developed more slowly in subjects with low MAP and was of low magnitude in subjects with high hematocrit values. In response to a prolongation of AO, from 1 to 4 min, the magnitude and duration of hyperemia increased significantly and similarly in both neonates and adults. We conclude that compared to adults neonates have a less pronounced ability to increase skin microcirculation in response to local ischemia. The normally low blood pressure and high hematocrit in newborn infants contribute further to this conclusion.
M Norman; L Gu; P Herin; B Fagrell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microvascular research     Volume:  41     ISSN:  0026-2862     ISO Abbreviation:  Microvasc. Res.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-22     Completed Date:  1991-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-38     Citation Subset:  IM    
Department of Pediatrics, Karolinska and St. Görans Childrens Hospital, Stockholm, Sweden.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology
Blood Flow Velocity
Blood Pressure
Hyperemia / physiopathology*
Infant, Newborn
Skin / blood supply*

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