Document Detail


Reactive hyperemia following one-beat coronary occlusions in the awake dog.
MedLine Citation:
PMID:  3953840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to examine the effect of alterations of cardiac activity during brief coronary artery occlusions on the subsequent reactive hyperemic response. Reactive hyperemia following coronary occlusions equal in duration to one cardiac cycle were examined in 12 chronically instrumented awake dogs while heart rate was maintained constant by cardiac pacing. During continuous pacing, one-beat coronary occlusions resulted in reactive hyperemia with excess flow equal to 220 +/- 23% blood flow debt repayment. When coronary occlusions of identical duration were performed while a single cycle of pacing was omitted during the interval of occlusion, the subsequent reactive hyperemia was decreased. Conversely, when coronary occlusion was produced during the first potentiated beat following a single cycle of paired ventricular stimulation, the reactive hyperemia was increased. Since, in the absence of coronary occlusion, omitting a single paced beat caused a transient decrease in coronary flow, while a single cycle of paired ventricular stimulation caused a brief increase in coronary flow, the reactive hyperemic responses were corrected for these perturbations in flow. Despite these corrections, the influence of alterations of myocardial activity during the interval of occlusion persisted, with the decreased reactive hyperemia when occlusion occurred during an omitted beat and increased hyperemia when occlusion was performed during a potentiated beat. These data indicate substantial coupling between myocardial activity during coronary occlusions as brief as one cardiac cycle in duration and the subsequent reactive hyperemic response.
Authors:
R J Bache; D S Hess
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-18     Completed Date:  1986-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H474-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / complications*,  physiopathology
Cardiac Pacing, Artificial
Coronary Circulation
Coronary Disease / complications*,  physiopathology
Diastole
Dogs
Electrocardiography
Hemodynamics
Hyperemia / etiology*,  physiopathology
Systole
Vascular Resistance
Wakefulness
Grant Support
ID/Acronym/Agency:
HL-20598/HL/NHLBI NIH HHS; HL-21872/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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