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Reactive electrophilic metabolites of aromatic amine and amide carcinogens .
MedLine Citation:
PMID:  23277055     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aromatic and heterocyclic amines are a major class of chemical mutagens and carcinogens. The toxicity of these compounds is a consequence of their metabolic activation. The best-characterized enzymatic pathways for aromatic amine activation lead to the formation of reactive esters such as N-acetoxyarylamines, which are believed to be precursors of short-lived nitrenium ions. In the 1960s, nitrenium ions were invoked as likely intermediates in the formation of arylamine-derived DNA adducts. More recently, nitrenium ion chemistry has been studied by methods such as trapping with azide ion, laser flash photolysis, and the preparation of highly stabilized of examples (e.g., dianisylnitrenium ion). In this review, we discuss the development of our understanding of nitrenium ion chemistry, with emphasis on their generation in biological systems and their reactions with critical targets such as DNA.
Authors:
P David Josephy; Michael Novak
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-59     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
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