Document Detail


Reactive desorption electrospray ionization for selective detection of the hydrolysis products of phosphonate esters.
MedLine Citation:
PMID:  17607799     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Reactive desorption electrospray ionization (reactive DESI) is demonstrated to be a rapid and sensitive method for the direct detection of alkyl methylphosphonic acids, the hydrolysis products and metabolites of the chemical warfare (CW) agents VX (S-2-diisopropylaminoethyl-O-ethyl methylphosphonothiolate) and GB (sarin, isopropylmethyl phosphonofluoridate). Rapid and sensitive detection of these compounds is readily achieved by performing DESI from a solid surface; detection specificity is enhanced by implementation of a heterogeneous ion/molecule reaction using boric acid in the spray solvent. The reagent ion H(2)BO(3) (-) generated in the spray readily reacts with condensed-phase alkyl MPA to form anionic adducts. The specificity of this chemical reaction, together with the characteristic fragmentation patterns of the reaction products, supplies a highly discriminatory detection method for methylphosphonic acid (MPA), ethylphosphonic acid (EMPA) and isopropyl methylphosphonic acid (IMPA) in complex matrices.
Authors:
Yishu Song; R Graham Cooks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of mass spectrometry : JMS     Volume:  42     ISSN:  1076-5174     ISO Abbreviation:  J Mass Spectrom     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504818     Medline TA:  J Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  1086-92     Citation Subset:  -    
Affiliation:
Department of Chemistry, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.
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