| Reactive changes of glial cells after optic nerve axotomy in adult rats. | |
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MedLine Citation:
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PMID: 8309639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied the glial response to optic nerve axotomy in vitro. Glial cells were obtained from normal and crush-axotomized optic nerves. In cultures from axotomized nerves, large numbers of astrocytes, oligodendrocyte progenitors and mature oligodendrocytes were found. Significantly fewer astrocytes and oligodendrocyte progenitors were present in cultures from normal nerves, mature oligodendrocytes did not occur. Proliferation and maturation of oligodendrocyte progenitor cells was only observed in cultures from axotomized nerves, suggesting the regulatory influence of blood-derived factors which are not present in normal nerves after in vitro axotomy. These data show that optic nerve injury enhances the ability of astrocytes, oligodendrocytes and their precursors to survive and/or proliferate in vitro. |
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Authors:
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C Przyrembel; M Bähr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 163 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-17 Completed Date: 1994-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 227-30 Citation Subset: IM |
Affiliation:
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Max-Planck-Institut für Entwicklungsbiologie, Tübingen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / cytology*, physiology Biological Markers / analysis Cells, Cultured Galactosylceramides / analysis Glial Fibrillary Acidic Protein / analysis Nerve Crush Neuroglia / cytology*, physiology Oligodendroglia / cytology, physiology Optic Nerve / cytology*, physiology* Organ Culture Techniques Rats Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Galactosylceramides; 0/Glial Fibrillary Acidic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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