| Reactive astrocytes in chronic active lesions of multiple sclerosis express co-stimulatory molecules B7-1 and B7-2. | |
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MedLine Citation:
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PMID: 12576238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Astrocytes in active lesions of multiple sclerosis (MS) express major histocompatibility (MHC) class II molecules, and may play an important role in the presentation of antigen to myelin-specific T cells.However, it has been postulated that astrocytes are unable to act as antigen-presenting cells (APCs) because they would lack the B7 co-stimulatory molecules to activate these T cells. By using double labeling immunofluorescence staining, we demonstrate that reactive astrocytes in chronic active plaques of multiple sclerosis express the co-stimulatory molecules B7-1 and B7-2, and hence have the necessary attributes to act as antigen-presenting cells. |
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Authors:
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Esther Zeinstra; Nadine Wilczak; Jacques De Keyser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 135 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-10 Completed Date: 2003-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigen-Presenting Cells / physiology Antigens, CD / analysis* Antigens, CD80 / analysis* Antigens, CD86 Astrocytes / immunology*, physiology Chronic Disease Female Humans Immunohistochemistry Male Membrane Glycoproteins / analysis* Middle Aged Multiple Sclerosis / immunology* T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/CD86 protein, human; 0/Membrane Glycoproteins |
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