Document Detail

Reactive angioendotheliomatosis in an infant.
MedLine Citation:
PMID:  10027526     Owner:  NLM     Status:  MEDLINE    
Reactive cutaneous angioendotheliomatosis (RCA) is an uncommon benign disease characterized by intravascular proliferation of endothelial cells. The observation of RCA in infants is exceedingly rare. We describe a case of RCA in a 3-month-old infant. The lesions were characterized by six small purpuric papules (1-2 mm in diameter), distributed on the thighs and neck. The general condition of the patient was good, with no lymphadenopathy, systemic involvement, or fever. The histopathologic features of a papule were characterized by the presence of cohesive aggregates of large mononucleated cells protruding into the lumina of dilated vessels and filling some of them completely. Neither an inflammatory infiltrate nor a proliferation of pericytes were present around blood vessels. Intravascular proliferating cells demonstrated positive staining for Ulex europaeus agglutinin 1 (UEA-1) and for Factor VIII-RA and CD34 antigens. The course of the disease was unremarkable with persistence of the lesions for 8 months; no treatment was started.
V Brazzelli; F Baldini; C Vassallo; F Borghini; M G Chiesa; R Rosso; G Borroni
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  21     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-07     Completed Date:  1999-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Department of Human and Hereditary Pathology, Institute of Dermatology and Pathology, University of Pavia, Policlinico S. Matteo IRCCS, Italy.
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MeSH Terms
Antigens, CD34 / analysis
Lectins / analysis
Lymphoma, Non-Hodgkin / metabolism,  pathology*
Plant Lectins*
Skin / chemistry,  pathology
Skin Neoplasms / metabolism,  pathology*
von Willebrand Factor / analysis
Reg. No./Substance:
0/Antigens, CD34; 0/Lectins; 0/Plant Lectins; 0/Ulex europaeus lectins; 0/von Willebrand Factor

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