Document Detail


Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus.
MedLine Citation:
PMID:  21781131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3 million deaths every year are attributed to these twin epidemics. Annually, ∼11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation.
METHODOLOGY: Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV).
RESULTS: A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB.
CONCLUSIONS: Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.
Authors:
Smriti Mehra; Nadia A Golden; Noton K Dutta; Cecily C Midkiff; X Alvarez; Lara A Doyle; Majdouline Asher; Kasi Russell-Lodrigue; Chris Monjure; Chad J Roy; James L Blanchard; Peter J Didier; Ronald S Veazey; Andrew A Lackner; Deepak Kaushal
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical primatology     Volume:  40     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  233-43     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Body Temperature
Body Weight
C-Reactive Protein / analysis
Latent Tuberculosis / complications*,  immunology,  microbiology,  physiopathology*
Macaca mulatta
Mycobacterium tuberculosis
Simian Acquired Immunodeficiency Syndrome / complications*,  immunology*,  virology
Simian immunodeficiency virus
Tuberculosis, Pulmonary / complications,  immunology,  microbiology,  physiopathology
Grant Support
ID/Acronym/Agency:
AI084793/AI/NIAID NIH HHS; AI089323/AI/NIAID NIH HHS; AI091457/AI/NIAID NIH HHS; HL10679/HL/NHLBI NIH HHS; P51 RR000164/RR/NCRR NIH HHS; R01 AI089323/AI/NIAID NIH HHS; R01 AI089323-01A1/AI/NIAID NIH HHS; R01 AI089323-02/AI/NIAID NIH HHS; R01 HL106790/HL/NHLBI NIH HHS; R01 HL106790-01/HL/NHLBI NIH HHS; R01 HL106790-02/HL/NHLBI NIH HHS; R21 AI091457/AI/NIAID NIH HHS; R21 AI091457-01/AI/NIAID NIH HHS; R21 AI091457-02/AI/NIAID NIH HHS; R21 RR026006/RR/NCRR NIH HHS; R21 RR026006-01A1/RR/NCRR NIH HHS; R21 RR026006-02/RR/NCRR NIH HHS; RR000164/RR/NCRR NIH HHS; RR020159/RR/NCRR NIH HHS; RR026006/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein
Comments/Corrections

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