Document Detail


Reactivation of cytomegalovirus in endometrial cells by estradiol.
MedLine Citation:
PMID:  3011615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study uses an in vitro model to test the influence of hormones on the replication and reactivation of cytomegalovirus (CMV) in endometrial tissue culture. Infection of epithelial cells of the endometrium with CMV in the presence of a high concentration of estradiol resulted in only a slightly higher yield of infectious virus. Progesterone did not cause any effect on viral replication. Arrest of CMV replication was achieved by reduction of the pH of the incubation medium. No infectious virus was detectable after incubation of infected cultures at pH 5.8. In the above-described conditions following the arrest of CMV replication by low pH, estradiol treatment was capable of reactivating the virus. The possibility that the increase in CMV infection observed in pregnancy is caused by reactivation of latent virus provoked by hormonal factors will be discussed.
Authors:
D Kleinman; I Sarov; V Insler
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  21     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-07     Completed Date:  1986-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  136-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cytomegalovirus / drug effects*,  physiology
Endometrium / cytology,  microbiology*
Estradiol / administration & dosage,  pharmacology*
Female
Humans
Progesterone / administration & dosage,  pharmacology*
Virus Replication / drug effects*
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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