Document Detail

Reactivation of antibody genes in Epstein-Barr virus transformed human B cell lines. A preliminary report.
MedLine Citation:
PMID:  2561727     Owner:  NLM     Status:  MEDLINE    
Three immortalised human B cell lines, which had either last their capacity to secrete specific antibody or secreted low levels of antibody were studied in an attempt to reactivate or enhance antibody synthesis. A variety of different stimuli known to cause activation, proliferation and differentiation of normal B cells were used including polyclonal activators and recombinant interferon. Four of them, (namely LPS, anti-IgM, IL2 and IL6) effectively increased specific antibody synthesis after three days of culture. These preliminary experiments show that the loss or decline in immunoglobulin production by immortalised human B cells is, at least in some cases, reversible.
G Skibiński; K James
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  37     ISSN:  0004-069X     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  1989  
Date Detail:
Created Date:  1990-08-14     Completed Date:  1990-08-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
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MeSH Terms
Antibody Formation / drug effects,  genetics*
B-Lymphocytes / cytology,  drug effects,  immunology*
Cell Line
Herpesvirus 4, Human*
Immune Sera / pharmacology*
Interleukins / pharmacology*
Lipopolysaccharides / pharmacology*
Reg. No./Substance:
0/Immune Sera; 0/Interleukins; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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