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Reactions of the tumour bed to lethally irradiated tumour cells, and the Révész effect.
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MedLine Citation:
PMID:  889686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subdermal inoculation of the foot of the rat with lethally irradiated (LI) Walker tumour (W256) cells, mixed with viable (V) W256 cells, decreased the latent period for initiation of allogeneic tumour growth without significantly affecting its rate. This Révész effect decreased with increase in the number of inoculated V cells, and with decrease in age of recipient. LI cells of a different (Y-P388) rat tumour exerted a Révész effect, even in recipients which had been immunized with LI (Y-P388) tumour cells. Local pre-irradiation of the site of inoculation of V cells decreased both the latent period and rate of tumour growth. It acted independently of a Révész effect, and the decrease in tumour growth rate was partly due to emigration of V cells from the inoculum, producing metastases. LI, but not heat-killed cells, induced prolonged swelling of the tumour bed in unimmunized and tumour-immunized rats, which, unlike inflammatory swelling, was inhibited by pre-irradiation of the foot. It is postulated that the Révész effect is due to enhancement of survival of V cells by trophic substances which are principally elaborated by LI (AND V) cells, but also by the tumour bed, due to innate growth and trophic reactions of its tissues to the presence of tumour cells.
Authors:
H A van den Brenk; M C Crowe; M G Stone
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of cancer     Volume:  36     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  94-104     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Carcinoma 256, Walker / immunology*,  metabolism,  pathology
Immunosuppression*
Neoplasm Transplantation
Radiation Effects*
Rats
Sarcoma, Yoshida / immunology
Time Factors
Transplantation, Homologous
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 7 Year: 1977
Volume: 36 Issue: 1
First Page: 94 Last Page: 104
ID: 2025437
PubMed Id: 889686

Reactions of the tumour bed to lethally irradiated tumour cells, and the Révész effect.
H. A. van den Brenk
M. C. Crowe
M. G. Stone



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  • Research Article


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