Document Detail

Reactions to intravenous contrast media. Part I: Severe and fatal cardiovascular reactions in a canine dehydration model.
MedLine Citation:
PMID:  6836112     Owner:  NLM     Status:  MEDLINE    
Investigations into the nature of severe and fatal reactions to contrast media have been severely limited by their unpredictable occurrence in the clinical setting and the absence of suitable laboratory models. The authors report their experience with a canine dehydration model. Intravenous administration of 2 ml/kg of 76% sodium methylglucamine diatrizoate resulted in vomiting, shock, inappropriate slowing of the heart rate, and death. ECG findings indicated suppression of sinoatrial node automaticity, a decrease in the rate of atrioventricular conduction, and depression of myocardial contractility. These results suggest two possible mechanisms: (a) enhanced vagal tone as the result of stimulation of the vasomotor center of the medulla or (b) accentuation of direct contrast-induced myocardial toxicity.
R W Katzberg; T W Morris; G Schulman; R T Faillace; L M Boylan; M J Foley; R F Spataro; H W Fischer
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  147     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiovascular System / drug effects*
Contrast Media / adverse effects*
Dehydration / physiopathology*
Diatrizoate Meglumine / adverse effects
Hemodynamics / drug effects
Kidney / radiography
Renal Circulation / drug effects
Time Factors
Grant Support
Reg. No./Substance:
0/Contrast Media; 131-49-7/Diatrizoate Meglumine

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