Document Detail

Reactions of nitric oxide and nitrogen dioxide with coenzyme Q: involvement of the isoprenic chain.
MedLine Citation:
PMID:  23334659     Owner:  NLM     Status:  Publisher    
The formation of a di-tert-alkyl nitroxide has been observed by Electron Spin Resonance during the exposure of coenzyme CoQ(10), in both the oxidized and reduced forms, to nitrogen dioxide (˙NO(2)) or to nitric oxide (˙NO) in the presence of oxygen. The same kind of nitroxide has been observed also with CoQ(1), CoQ(3) or with 1-phenyl-3-methyl-2-butene, chosen as model compounds. In all cases, the formation of the nitroxide may be justified only by admitting the involvement of the isoprenic chain of the coenzymes and in particular the addition of ˙NO(2) to the double bond. A mechanism which accounts for the formation of the nitroxide as well as the other compounds observed in the reactions is proposed and confirmed by a spectroscopic investigation (FT-IR, (1)H NMR, X-ray analysis) and by ESI-MS.
Paola Astolfi; Laurence Charles; Didier Gigmes; Lucedio Greci; Corrado Rizzoli; Federico Sorana; Pierluigi Stipa
Related Documents :
3029719 - Reactivity of modified ribose moieties of guanosine: new cleavage reactions mediated by...
24606049 - Access to cinnamyl derivatives from arenes and allyl esters by a biomimetic aerobic oxi...
25452099 - Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenat...
23530339 - Phosphorus recovery as alpo4 from beneficially reused aluminium sludge arising from wat...
21962849 - Sonolytic degradation of dimethoate: kinetics, mechanisms and toxic intermediates contr...
23452079 - Structural analysis of aliphatic versus aromatic substrate specificity in a copper amin...
21595649 - Methaemalbumin formation in sickle cell disease: effect on oxidative protein modificati...
22650009 - Carbohydrate content and antioxidative potential of the seed of three edible indica ric...
25238919 - Synthesis of 4-hydroxy-2(1h)-quinolone derived chalcones, pyrazolines and their antimic...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Dipartimento SIMAU, Università Politecnica delle Marche, Via Brecce Bianche 12, I-60131 Ancona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  On the possibility to affect the course of glycaemia, insulinaemia, and perceived hunger/satiety to ...
Next Document:  Endoscopic ultrasound and pancreatic applications: what the radiologist needs to know.