Document Detail


Reaction time deficits and Parkinson's disease.
MedLine Citation:
PMID:  9809316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Controversy surrounds the existence and nature of reaction time deficits in Parkinson's disease. Three areas of research are reviewed: the use of precues to speed movement (motor preprogramming), the effects of medication on reaction time, and simple reaction times. No evidence is found for a motor preprogramming deficit, and the presence of a parkinsonian reaction time deficit after medication withdrawal is found to be dependent upon experimental design and the withdrawal method used. Parkinson's disease is found to cause a consistent deficit in simple reaction time. A quantitative analysis of past studies reveals that a parkinsonian reaction time deficit is more likely to be present in tasks that controls can perform with a fast reaction time. This relationship between deficit and control group reaction time applies to choice, but not simple, reaction time tasks. Many studies compare patient and control choice reaction times across experimental conditions that cause control reaction time to vary. The authors of these studies should consider whether their results can be explained in terms of the simple relationship between patient reaction time deficit and control reaction time before drawing more complex conclusions from their data.
Authors:
J Gauntlett-Gilbert; V J Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  22     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-26     Completed Date:  1999-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-81     Citation Subset:  IM    
Affiliation:
School of Psychology, University of St. Andrews, UK.
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MeSH Terms
Descriptor/Qualifier:
Dopamine / therapeutic use
Humans
Parkinson Disease / drug therapy,  physiopathology*
Reaction Time / drug effects,  physiology*

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