Document Detail

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.
MedLine Citation:
PMID:  19926280     Owner:  NLM     Status:  MEDLINE    
We report here a simple entry into naphtho[2,3-d]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.
Maria M M Santos; Nat?lia Faria; Jim Iley; Simon J Coles; Michael B Hursthouse; M Luz Martins; Rui Moreira
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
i-Med.UL, Faculdade de Farm?cia, Universidade de Lisboa, Av. For?as Armadas, Lisboa, Portugal.
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MeSH Terms
Antifungal Agents / chemical synthesis*,  chemistry,  pharmacology
Candida / drug effects
Isoxazoles / chemistry*
Microbial Sensitivity Tests
Naphthoquinones / chemical synthesis,  chemistry*,  pharmacology
Reg. No./Substance:
0/Antifungal Agents; 0/Isoxazoles; 0/Naphthoquinones; 130-15-4/1,4-naphthoquinone

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