Document Detail

Reaction of the leukocytes of melanoma patients and control donors, including pregnant women, with melanoma- and fetus-derived materials.
MedLine Citation:
PMID:  6965229     Owner:  NLM     Status:  MEDLINE    
Using a one-stage capillary leukocyte migration inhibition assay, we examined peripheral blood leukocytes from 97 patients with malignant melanoma, 194 pregnant women, and 123 non-pregnant donors for their reactivity with materials from fetal and melanomatous tissues. As in previous studies, we found melanoma extracts selectively to inhibit melanoma patients' leukocytes. First-trimester fetal extracts also selectively inhibited melanoma patients' leukocytes, suggesting their cross-reactivity with melanoma-derived antigens. We could not localize the source of the inhibitory materials within the fetuses. We found no evidence that pregnant women were selectively immunized to fetal or melanoma extracts, regardless of their parity or the stage of their pregnancy.
A J Cochran; G Todd; D M Hart; L J Morrison; R M MacKie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer immunology, immunotherapy : CII     Volume:  14     ISSN:  0340-7004     ISO Abbreviation:  Cancer Immunol. Immunother.     Publication Date:  1982  
Date Detail:
Created Date:  1988-06-20     Completed Date:  1988-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605732     Medline TA:  Cancer Immunol Immunother     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90024.
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MeSH Terms
Cell Migration Inhibition*
Fetus / immunology*
Leukocytes / immunology*
Melanoma / immunology*
Placenta / immunology
Pregnancy / immunology*

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