Document Detail


Reaction of beta-propiolactone with amino acids and its specificity for methionine.
MedLine Citation:
PMID:  5637366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The reactions of beta-propiolactone with amino acids were investigated under various conditions of pH and temperature to find those under which the reagent acted with specificity. 2. At pH9.0 and 22 degrees , after 15min. of reaction, at least 85% of each amino acid had reacted, methionine and cystine being the most reactive. 3. At pH7.0 and 22 degrees most amino acids reacted; methionine, cystine and histidine reacted almost entirely, and proline and lysine to a significantly smaller extent. 4. At pH3.0 and 22 degrees further specificity was obtained; methionine and cystine were the only reactive amino acids. 5. Reaction at pH3.0 and 0 degrees was specific for methionine; it was the only amino acid modified even after 145hr. of reaction.
Authors:
M A Taubman; M Z Atassi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  106     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1968 Feb 
Date Detail:
Created Date:  1968-04-10     Completed Date:  1968-04-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  829-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids*
Autoanalysis
Chemical Phenomena
Chemistry
Cold Temperature
Cystine
Histidine
Hydrogen-Ion Concentration
Isoleucine
Lactones*
Leucine
Lysine
Methionine*
Phenylalanine
Proline
Tyrosine
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Lactones; 147-85-3/Proline; 55520-40-6/Tyrosine; 56-87-1/Lysine; 56-89-3/Cystine; 61-90-5/Leucine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 71-00-1/Histidine; 73-32-5/Isoleucine
Comments/Corrections

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