| Reaching the limit of the oculomotor plant: 3D kinematics after abducens nerve stimulation during the torsional vestibulo-ocular reflex. | |
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MedLine Citation:
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PMID: 22993439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence shows that the oculomotor plant is capable of implementing aspects of three-dimensional kinematics such as Listing's law and the half-angle rule. But these studies have only examined the eye under static conditions or with movements that normally obey these rules (e.g., saccades and pursuit). Here we test the capability of the oculomotor plant to rearrange itself as necessary for non-half-angle behavior. Three monkeys (Macaca mulatta) fixated five vertically displaced targets along the midsagittal plane while sitting on a motion platform that rotated sinusoidally about the naso-occipital axis. This activated the torsional, rotational vestibulo-ocular reflex, which exhibits a zero-angle or negative-angle rule (depending on the visual stimulus). On random sinusoidal cycles, we stimulated the abducens nerve and observed the resultant eye movements. If the plant has rearranged itself to implement this non-half-angle behavior, then stimulation should reveal this behavior. On the other hand, if the plant is only capable of half-angle behavior, then stimulation should reveal a half-angle rule. We find the latter to be true and therefore additional neural signals are likely necessary to implement non-half-angle behavior. |
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Authors:
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Eliana M Klier; Hui Meng; Dora E Angelaki |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-20 Completed Date: 2012-12-03 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 13237-43 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA. eklier@cns.bcm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abducens Nerve
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physiology* Animals Biomechanics Electric Stimulation Eye Movements / physiology* Feedback, Physiological / physiology Functional Laterality / physiology Hand Macaca mulatta Male Movement / physiology* Oculomotor Muscles / innervation, physiology* Reflex, Vestibulo-Ocular / physiology* Torso* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY015271/EY/NEI NIH HHS; R01-EY15271/EY/NEI NIH HHS; R03- 010450//PHS HHS |
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