Document Detail

Reaching the limit of the oculomotor plant: 3D kinematics after abducens nerve stimulation during the torsional vestibulo-ocular reflex.
MedLine Citation:
PMID:  22993439     Owner:  NLM     Status:  MEDLINE    
Accumulating evidence shows that the oculomotor plant is capable of implementing aspects of three-dimensional kinematics such as Listing's law and the half-angle rule. But these studies have only examined the eye under static conditions or with movements that normally obey these rules (e.g., saccades and pursuit). Here we test the capability of the oculomotor plant to rearrange itself as necessary for non-half-angle behavior. Three monkeys (Macaca mulatta) fixated five vertically displaced targets along the midsagittal plane while sitting on a motion platform that rotated sinusoidally about the naso-occipital axis. This activated the torsional, rotational vestibulo-ocular reflex, which exhibits a zero-angle or negative-angle rule (depending on the visual stimulus). On random sinusoidal cycles, we stimulated the abducens nerve and observed the resultant eye movements. If the plant has rearranged itself to implement this non-half-angle behavior, then stimulation should reveal this behavior. On the other hand, if the plant is only capable of half-angle behavior, then stimulation should reveal a half-angle rule. We find the latter to be true and therefore additional neural signals are likely necessary to implement non-half-angle behavior.
Eliana M Klier; Hui Meng; Dora E Angelaki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2012-12-03     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13237-43     Citation Subset:  IM    
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Abducens Nerve / physiology*
Electric Stimulation
Eye Movements / physiology*
Feedback, Physiological / physiology
Functional Laterality / physiology
Macaca mulatta
Movement / physiology*
Oculomotor Muscles / innervation,  physiology*
Reflex, Vestibulo-Ocular / physiology*
Grant Support
R01 EY015271/EY/NEI NIH HHS; R01-EY15271/EY/NEI NIH HHS; R03 DC010450/DC/NIDCD NIH HHS; R03- 010450//PHS HHS

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