| Re-stenosis after drug-eluting stents in cardiac allograft vasculopathy. | |
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MedLine Citation:
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PMID: 18503959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiac allograft vasculopathy (CAV) constitutes a primary cause of death after heart transplantation. Balloon angioplasty and bare metal stents have been used for revascularization but they are associated with a high risk of re-stenosis. Limited data have shown favorable results with drug-eluting stents (DES). This study examines the rate of re-stenosis for DES in CAV as well as predictors for its occurrence. METHODS: Cardiac transplant patients who received at least one DES for a previously untreated coronary lesion were included. These patients were retrospectively followed until February 2007. Re-stenosis was defined as >or=50% lumen diameter narrowing on coronary angiography at the site of the DES. RESULTS: During the study period, 35 patients underwent percutaneous coronary intervention (PCI) on a total of 84 de novo lesions. The mean follow-up was 22 +/- 14 months. Twenty-six (31%) lesions developed re-stenosis during follow-up. Re-stenosis rates were 18%, 21% and 26% at 6, 9 and 12 months, respectively. Predictors of re-stenosis included non-white race, ischemic etiology, intervention precipitated by symptoms and severe stenosis (>/=90% stenosis) of the target lesion. CONCLUSIONS: Use of DES has a favorable outcome when used in heart transplant patients for the treatment of CAV. An aggressive strategy for the treatment of CAV using DES may provide good long-term outcome compared with other available therapies. |
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Authors:
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Raed A Aqel; Bryan J Wells; Fadi G Hage; Jose Tallaj; Raymond Benza; Salpy Pamboukian; Barry Rayburn; David McGiffin; James Kirklin; Robert Bourge |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-04-23 |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 27 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-27 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 610-5 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Disease, University of Alabama at Birmingham, Alabama 35294, USA. raed.aqel@med.va.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Coronary Restenosis / epidemiology, etiology, therapy* Drug-Eluting Stents* Female Graft Occlusion, Vascular / etiology* Heart Transplantation / adverse effects* Humans Male Middle Aged Transplantation, Homologous Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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