Document Detail

Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition.
MedLine Citation:
PMID:  1471456     Owner:  NLM     Status:  MEDLINE    
Thyroxine-binding globulin, the highest affinity thyroid hormone binder of rat serum, was studied during 28 days of dietary protein restriction (6% protein vs 18% protein in isocaloric control diet) or energy restriction (60% intake of control diet). Studies were performed on male rats aged four weeks at the beginning of experiments: the animals had reached the ontogenic stage when the thyroxine-binding globulin had declined, after its high postnatal surge, to undetectable levels. Short-term administration (seven days) of one or the other restricted diet similarly induced resynthesis of the protein. Its serum concentrations reached 26-46% of those measured in eight-day pups (peak of the neonatal surge) and its liver mRNAs showed corresponding enhanced signals. Serum T4 binding activities were increased, although concomitantly transthyretin, second specific T4 carrier of the rat serum, decreased markedly (65-75% of controls) in response to the dietary restrictions. Longer-term diet administration (14 or 28 days) resulted in the further increase of the thyroxine-binding globulin in the protein-restricted rats, in contrast to its decline and eventual disappearance in the energy-restricted animals. Protein restriction was associated with increased total and free T3 serum concentrations, in contrast to energy restriction which little affected these parameters. These studies reveal rat thyroxine-binding globulin as a positive (increasing), highly sensitive reactant of malnutrition, able to discriminate between energy deficiency and composition dysequilibrium of diets. They suggest that up-regulation of its synthesis in the two dietary models involves differential mechanisms.
M Rouaze-Romet; L Savu; R Vranckx; F Bleiberg-Daniel; B Le Moullac; P Gouache; E A Nunez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  127     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  441-8     Citation Subset:  IM    
U224 Inserm, Faculté de médecine Xavier Bichat, Paris, France.
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MeSH Terms
Energy Intake*
Liver / metabolism
Nutrition Disorders / blood*
Osmolar Concentration
Prealbumin / metabolism
Protein Deficiency / blood*
RNA, Messenger / metabolism
Rats, Wistar
Thyroid Hormones / metabolism
Thyroxine-Binding Proteins / genetics,  metabolism*
Reg. No./Substance:
0/Prealbumin; 0/RNA, Messenger; 0/Thyroid Hormones; 0/Thyroxine-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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