Document Detail


Re-examination of effect of paracetamol on serum uric acid measured by phosphotungstic acid reduction.
MedLine Citation:
PMID:  464539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The drug paracetamol (N-acetyl-p-aminophenol; acetaminophen) caused a spurious increase in serum uric acid measured by phosphotungstic acid reduction methods. However, the increase was less than 0.12 mmol/1 at plasma levels of paracetamol found in overdosage (40 mg/100 ml) and was small at therapeutic concentrations (less than 4 mg/100 ml). It is concluded that few patients with joint pain who have taken paracetamol paracetamol as an analgesic will have clinically misleading values for serum uric acid.
Authors:
M Smith; R B Payne
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  16     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  pharmacology*
False Positive Reactions
Gout / blood,  diagnosis
Humans
Methods
Oxidation-Reduction
Phosphotungstic Acid
Substance-Related Disorders
Uric Acid / blood*
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen; 12067-99-1/Phosphotungstic Acid; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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