Document Detail


Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.
MedLine Citation:
PMID:  23148228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in cytoplasmic Ca(2+) concentration, resulting from activation of intracellular Ca(2+) channels within the endoplasmic reticulum, regulate several aspects of cellular growth and differentiation. Ca(2+) homeostasis endoplasmic reticulum protein (CHERP) is a ubiquitously expressed protein that has been proposed as a regulator of both major families of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), with resulting effects on mitotic cycling. However, the manner by which CHERP regulates intracellular Ca(2+) channels to impact cellular growth is unknown. Here, we challenge previous findings that CHERP acts as a direct cytoplasmic regulator of IP(3)Rs and RyRs and propose that CHERP acts in the nucleus to impact cellular proliferation by regulating the function of the U2 snRNA spliceosomal complex. The previously reported effects of CHERP on cellular growth therefore are likely indirect effects of altered spliceosomal function, consistent with prior data showing that loss of function of U2 snRNP components can interfere with cell growth and induce cell cycle arrest.
Authors:
Yaping Lin-Moshier; Peter J Sebastian; Leeann Higgins; Natalie D Sampson; Jane E Hewitt; Jonathan S Marchant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-12
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  288     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-02-28     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Calcium / metabolism*
Calcium Signaling
Cell Cycle
Cell Membrane / metabolism
Cytoplasm / metabolism
DNA-Binding Proteins / metabolism*
Endoplasmic Reticulum / metabolism
Gene Expression Regulation*
HEK293 Cells
Homeostasis
Humans
Inositol 1,4,5-Trisphosphate Receptors / metabolism
Jurkat Cells
Membrane Proteins / metabolism*
Molecular Sequence Data
Mutation
Nucleosomes / metabolism*
RNA Interference
RNA-Binding Proteins / metabolism*
Ribonucleoproteins / chemistry,  metabolism*
Ryanodine Receptor Calcium Release Channel / metabolism
Spliceosomes / metabolism
Subcellular Fractions / metabolism
Grant Support
ID/Acronym/Agency:
GM088790/GM/NIGMS NIH HHS; //Biotechnology and Biological Sciences Research Council
Chemical
Reg. No./Substance:
0/CHERP protein, human; 0/DNA-Binding Proteins; 0/Inositol 1,4,5-Trisphosphate Receptors; 0/Membrane Proteins; 0/Nucleosomes; 0/RNA-Binding Proteins; 0/Ribonucleoproteins; 0/Ryanodine Receptor Calcium Release Channel; 0/SR140 protein, human; SY7Q814VUP/Calcium
Comments/Corrections

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