| Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling. | |
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MedLine Citation:
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PMID: 23148228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in cytoplasmic Ca(2+) concentration, resulting from activation of intracellular Ca(2+) channels within the endoplasmic reticulum, regulate several aspects of cellular growth and differentiation. Ca(2+) homeostasis endoplasmic reticulum protein (CHERP) is a ubiquitously expressed protein that has been proposed as a regulator of both major families of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), with resulting effects on mitotic cycling. However, the manner by which CHERP regulates intracellular Ca(2+) channels to impact cellular growth is unknown. Here, we challenge previous findings that CHERP acts as a direct cytoplasmic regulator of IP(3)Rs and RyRs and propose that CHERP acts in the nucleus to impact cellular proliferation by regulating the function of the U2 snRNA spliceosomal complex. The previously reported effects of CHERP on cellular growth therefore are likely indirect effects of altered spliceosomal function, consistent with prior data showing that loss of function of U2 snRNP components can interfere with cell growth and induce cell cycle arrest. |
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Authors:
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Yaping Lin-Moshier; Peter J Sebastian; Leeann Higgins; Natalie D Sampson; Jane E Hewitt; Jonathan S Marchant |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-11-12 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 288 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-07 Completed Date: 2013-02-28 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 355-67 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Calcium / metabolism* Calcium Signaling Cell Cycle Cell Membrane / metabolism Cytoplasm / metabolism DNA-Binding Proteins / metabolism* Endoplasmic Reticulum / metabolism Gene Expression Regulation* HEK293 Cells Homeostasis Humans Inositol 1,4,5-Trisphosphate Receptors / metabolism Jurkat Cells Membrane Proteins / metabolism* Molecular Sequence Data Mutation Nucleosomes / metabolism* RNA Interference RNA-Binding Proteins / metabolism* Ribonucleoproteins / chemistry, metabolism* Ryanodine Receptor Calcium Release Channel / metabolism Spliceosomes / metabolism Subcellular Fractions / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM088790/GM/NIGMS NIH HHS; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/CHERP protein, human; 0/DNA-Binding Proteins; 0/Inositol 1,4,5-Trisphosphate Receptors; 0/Membrane Proteins; 0/Nucleosomes; 0/RNA-Binding Proteins; 0/Ribonucleoproteins; 0/Ryanodine Receptor Calcium Release Channel; 0/SR140 protein, human; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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