Document Detail

Re-evaluation of refractory anemia with excess blasts in transformation.
MedLine Citation:
PMID:  11597728     Owner:  NLM     Status:  MEDLINE    
The category 'refractory anemia with excess blasts in transformation (RAEBt)' consists of two sub-sets; one group is categorized based on the percentage of blasts in the marrow (> or =20%) and other is based on the percentage of blasts in the peripheral blood (> or =5%). We separated RAEBt patients based on these two criteria and compared hematologic and clinical relevance to assess the reasonable basis for the new classification. All RAEBt patients showing peripheral blood (PB) blasts of > or =5% were re-classified as RAEB by the WHO classification. This subset of RAEBt patients had lower percentages of bone marrow (BM) blasts, and notably they showed frequent complex cytogenetic abnormalities, including -5/5q- and/or -7/7q-. Moreover, the RAEBt patients of this group had shorter survivals compared to RAEBt patients with BM blasts between 20 and 30%. We next assessed hematologic and clinical relevance between refractory anemia with excess blasts (RAEB) and RAEBt patients with PB blasts of > or =5%. Except for the percentage of blasts in the PB (P=0.0037) and BM (P=0.0073), there was no significant difference in hematologic or clinical features between RAEB patients with BM blasts of > or =11% and RAEBt patients with PB blasts of > or =5%. When MDS patients with PB blasts of > or =5% (RAEBt by the FAB classification) were included as RAEB-II based on the "MDS 2000 classification', there was a high frequency of patients with complex chromosome changes, involving 5q and 7q, with significant poorer outcome compared to those with RAEB-I. Although it is still controversial whether MDS patients with BM blasts 20% or more should be considered as acute leukemia, the utilization of the 'MDS 2000 classification' might be useful to designate MDS patients diagnosed based on the percentage of blasts in the peripheral blood.
K Ohyashiki; J Nishimaki; N Shoji; K Miyazawa; Y Kimura; J H Ohyashiki
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  25     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  933-9     Citation Subset:  IM    
First Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishioshinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan.
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MeSH Terms
Anemia, Refractory, with Excess of Blasts / classification*,  genetics,  mortality
Blood Cells / pathology
Bone Marrow Cells / pathology
Chromosome Aberrations
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 7
Cytogenetic Analysis
Databases, Factual
Lymphocyte Activation*
Middle Aged
Myelodysplastic Syndromes / classification,  genetics,  mortality
Survival Rate

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