| Re-evaluation of phenotypic expression in undifferentiated-type early gastric adenocarcinomas using mucin core protein and CDX2. | |
| | |
MedLine Citation:
|
PMID: 22829163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Undifferentiated-type early gastric adenocarcinomas are generally classified into two groups: pure undifferentiated-type adenocarcinomas, which naturally develop as undifferentiated-type without a glandular component; and mixed differentiated/undifferentiated-type adenocarcinomas, which are associated with some vestigial glandular component and presumably develop from differentiated-type adenocarcinoma. The differences in phenotypic expression between these two groups were examined using mucin core protein and CDX2. METHODS: A total of 210 lesions of undifferentiated-type early gastric adenocarcinoma less than 25 mm in diameter were classified into four categories (gastric type, gastrointestinal type, intestinal type, and null type) based on their MUC5AC, MUC6, MUC2, and CDX2 immunoprofiles. RESULTS: Gastric type was significantly (p < 0.01) decreased and gastrointestinal type was significantly (p < 0.01) increased both in pure undifferentiated-type adenocarcinomas and in mixed differentiated/undifferentiated-type adenocarcinomas when CDX2 was applied to mucin core protein. In the pure undifferentiated-type adenocarcinomas, gastric type decreased and gastrointestinal type increased as tumor size increased (p < 0.05). In contrast, in the mixed differentiated/undifferentiated-type adenocarcinomas, gastrointestinal type was most common even in small-sized (≤10 mm) carcinomas and was generally stable regardless of tumor size. In submucosal carcinomas, gastrointestinal type decreased and gastric type and intestinal type increased during carcinoma invasion from the intramucosal to submucosal parts (p < 0.05). The positivity rates for all phenotypic markers, especially gastric markers, tended to decrease during submucosal invasion. CONCLUSIONS: CDX2 is a sensitive marker for assessing intestinal phenotypic expression, and it is likely that there are two different pathways of tumor progression in undifferentiated-type adenocarcinoma of the stomach, according to phenotypic expression. |
| | |
Authors:
|
Satoshi Ikarashi; Ken Nishikura; Yoichi Ajioka; Yutaka Aoyagi |
Related Documents
:
|
1175173 - Mathematic models for cancer chemotherapy: pharmacokinetic and cell kinetic considerati... 22509193 - Applications of functionalized fullerenes in tumor theranostics. 10465553 - A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyin... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-25 |
Journal Detail:
|
Title: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Volume: - ISSN: 1436-3291 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100886238 Medline TA: Gastric Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ...
Next Document: Variation of the baseline characteristics and treatment parameters over time: an analysis of 15 yea...