Document Detail

Re-emergence of fatal human influenza A subtype H5N1 disease.
MedLine Citation:
PMID:  14987888     Owner:  NLM     Status:  MEDLINE    
Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.
J S M Peiris; W C Yu; C W Leung; C Y Cheung; W F Ng; J M Nicholls; T K Ng; K H Chan; S T Lai; W L Lim; K Y Yuen; Y Guan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  363     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-27     Completed Date:  2004-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  617-9     Citation Subset:  AIM; IM    
Department of Microbiology and Pathology, University of Hong Kong and Queen Mary Hospital, Pokfulam, Hong Kong SAR, People's Republic of China.
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MeSH Terms
China / epidemiology
Disease Outbreaks / statistics & numerical data
Hong Kong / epidemiology
Influenza A Virus, H5N1 Subtype
Influenza A virus / isolation & purification
Influenza in Birds / epidemiology*,  transmission,  virology
Influenza, Human / epidemiology*,  transmission*,  virology
Poultry Diseases / epidemiology,  transmission
Zoonoses / epidemiology*
Grant Support
Comment In:
Lancet. 2004 Feb 21;363(9409):582-3   [PMID:  14987878 ]

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