| Re-elevation of D-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection. | |
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MedLine Citation:
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PMID: 20936292 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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D-dimer measurement is a useful complementary initial diagnostic marker in patients with acute aortic dissection (AAD). However, it has not been clarified whether serial measurements of D-dimer are useful during in-hospital management of Stanford type B AAD. We studied 30 patients who were admitted with diagnosis of Stanford type B AAD and treated conservatively. D-dimer was serially measured on admission and then every 5 days during hospitalization. Patients were divided into two groups according to the presence or absence of re-elevation of D-dimer during hospitalization, in which D-dimer transition were biphasic and latter peak >10.0 μg/ml. Re-elevation of D-dimer was observed in 17 patients. There were no differences in atherosclerotic risk factors, blood pressure on admission, D-dimer level on admission, extent of AAD, and false lumen patency. Patients with re-elevation of D-dimer showed higher incidence of re-dissection and/or venous thromboembolism (VTE). Peak D-dimer level in patients with re-dissection and/or VTE was significantly higher than that without these complications (p = 0.005). In conclusion, serial measurements of D-dimer are useful for early detection of re-dissection or VTE in patients with Stanford type B AAD, which may contribute to the prevention of disastrous consequences such as pulmonary embolism and extension of AAD. |
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Authors:
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Yusuke Jo; Toshihisa Anzai; Koji Ueno; Hidehiro Kaneko; Takashi Kohno; Yasuo Sugano; Yuichiro Maekawa; Tsutomu Yoshikawa; Hideyuki Shimizu; Ryohei Yozu; Satoshi Ogawa |
Publication Detail:
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Type: Journal Article Date: 2010-10-09 |
Journal Detail:
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Title: Heart and vessels Volume: 25 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 509-14 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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