| Re-activation of atrophic motor Schwann cells after hypoglossal-facial nerve anastomosis. | |
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MedLine Citation:
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PMID: 18337003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Facial nerve lesions are common in humans and often require surgical intervention. If repair is delayed, reinnervation can be facilitated by transposing the freshly cut hypoglossal nerve end-to-end directly to the distal facial nerve, allowing for uncompromised hypoglossal axons to reinnervate the denervated facial musculature (hypoglossal-facial anastomosis, HFA). Schwann cells (SCs) in the distal nerve stump have an important function in promoting axonal regeneration by expressing multiple regeneration-associated proteins. Chronically denervated SCs cease to express those factors, but it is unknown whether they can be reactivated by fresh axonal sprouts and regain part of their function. We evaluated SC function and viability in distal facial nerve stump of rats at various time points after chronic denervation as well as following immediate or delayed HFA by assessing their expression of growth-associated protein 43 kDa (GAP-43) and the neuregulin receptors erbB2 and erbB4. Our results show that maximal upregulation of those factors in denervated SCs occurred a few weeks after nerve transection, indicating that a short period of denervation might even be beneficial before nerve repair. Motor SCs denervated for 32 weeks had downregulated their activity and ceased to express the regeneration-associated factors. SCs immediately re-expressed GAP-43, erbB2, and erbB4 following contact with fresh hypoglossal motor axons, demonstrating they are competent to promote regeneration even after long-term denervation. |
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Authors:
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Maria Adele Rueger; Sandra Aras; Orlando Guntinas-Lichius; Wolfram F Neiss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-06 |
Journal Detail:
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Title: Neuroscience letters Volume: 434 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-07-10 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Institut I für Anatomie, der Universität zu Köln, D-50924 Köln, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrophy / physiopathology, prevention & control, surgery Biological Markers / metabolism Denervation Facial Nerve / cytology, physiology*, surgery Facial Nerve Injuries / physiopathology, surgery* Female GAP-43 Protein / metabolism Glycoproteins / metabolism Growth Cones / physiology, ultrastructure Hypoglossal Nerve / cytology, physiology, surgery Immunohistochemistry Motor Neurons / cytology, physiology* Nerve Regeneration / physiology* Nerve Transfer / methods* Neuregulin-1 / metabolism Rats Rats, Wistar Receptor, Epidermal Growth Factor / metabolism Receptor, erbB-2 Recovery of Function / physiology Schwann Cells / cytology, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Erbb2 protein, rat; 0/GAP-43 Protein; 0/Glycoproteins; 0/Neuregulin-1; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/Receptor, erbB-2; EC 2.7.10.1/receptor tyrosine-protein kinase erbB-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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