| Raynaud's phenomenon as a manifestation of parvovirus B19 infection: case reports and review of parvovirus B19 rheumatic and vasculitic syndromes. | |
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MedLine Citation:
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PMID: 10722434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection with human parvovirus B19 is manifested as erythema infectiosum, transient aplastic crisis, or hydrops fetalis. Rheumatic manifestations include arthropathy and various vasculitic syndromes. Isolated Raynaud's phenomenon due to parvovirus B19 has never been described. We report on 2 previously healthy sisters with new-onset Raynaud's phenomenon accompanied by severe generalized polyarthralgia. A full workup was negative, except serology for parvovirus B19, which was positive. All symptoms gradually subsided within 3-5 months, and no recurrence has been noted during the 3 years since onset. We review all the studies in the English-language literature on parvovirus B19-induced rheumatic and vasculitic syndromes. We hypothesize that the pathogenesis of Raynaud's phenomenon in our patients involved immune-mediated endothelial damage leading to platelet activation and vasoconstriction. We recommend that in cases of unexplained Raynaud's phenomenon, serology for parvovirus B19 be included in the evaluation. |
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Authors:
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L Harel; R Straussberg; H Rudich; A H Cohen; J Amir |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 30 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-19 Completed Date: 2000-05-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 500-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva 49 202, Israel. gvharel@netvision.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibodies, Viral / blood Erythema Infectiosum / virology* Female Humans Parvovirus B19, Human* / immunology Raynaud Disease / virology* Rheumatic Diseases / virology* Syndrome Vasculitis / virology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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