Document Detail

Raynaud, digital ulcers and calcinosis in scleroderma.
MedLine Citation:
PMID:  22835924     Owner:  NLM     Status:  MEDLINE    
Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with systemic sclerosis. Digital ulcers are seen in more than half of the patients with scleroderma. Hospitalizations, ischemic complications and impairment of hand function are frequently observed in patients with digital ulcers, especially if treatment is delayed. Rapid and intensive treatment escalation in patients with scleroderma and refractory Raynaud's phenomenon is one of the most effective preventive action available in order to avoid the development of digital ulcers and tissue loss.
Alejandro Nitsche
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-25
Journal Detail:
Title:  Reumatología clinica     Volume:  8     ISSN:  1885-1398     ISO Abbreviation:  Reumatol Clin     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-04     Completed Date:  2013-02-25     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  101293923     Medline TA:  Reumatol Clin     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. All rights reserved.
Specialist in rheumatology, Servicio de Reumatología, Hospital Alemán; Consultorio de Raynaud, Esclerodermia e Hipertensión Arterial Pulmonar, Sanatorio San José, Ciudad Autónomade Buenos Aires, Argentina.
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MeSH Terms
Calcinosis / drug therapy,  etiology*,  physiopathology
Cell Hypoxia
Combined Modality Therapy
Endothelin-1 / physiology
Endothelium, Vascular / pathology,  physiopathology
Fingers / blood supply,  pathology
Foot Ulcer / drug therapy,  etiology,  physiopathology,  surgery
Ischemia / drug therapy,  etiology,  physiopathology,  prevention & control
Multicenter Studies as Topic
Platelet Aggregation
Platelet Aggregation Inhibitors / therapeutic use
Randomized Controlled Trials as Topic
Raynaud Disease / diagnosis,  drug therapy,  etiology*,  therapy
Scleroderma, Systemic / complications*,  diagnosis,  drug therapy,  physiopathology
Skin Ulcer / drug therapy,  etiology*,  physiopathology,  surgery
Sulfonamides / therapeutic use
Thrombophilia / etiology
Thrombosis / etiology,  prevention & control
Toes / blood supply,  pathology
Vasoconstriction / physiology
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Endothelin-1; 0/Platelet Aggregation Inhibitors; 0/Sulfonamides; 0/Vasodilator Agents; Q326023R30/bosentan

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