| Rats avoid high magnetic fields: dependence on an intact vestibular system. | |
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MedLine Citation:
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PMID: 17585969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High strength static magnetic fields are thought to be benign and largely undetectable by mammals. As magnetic resonance imaging (MRI) machines increase in strength, however, potential aversive effects may become clinically relevant. Here we report that rats find entry into a 14.1 T magnet aversive, and that they can detect and avoid entry into the magnet at a point where the magnetic field is 2 T or lower. Rats were trained to climb a ladder through the bore of a 14.1 T superconducting magnet. After their first climb into 14.1 T, most rats refused to re-enter the magnet or climb past the 2 T field line. This result was confirmed in a resistive magnet in which the magnetic field was varied from 1 to 14 T. Detection and avoidance required the vestibular apparatus of the inner ear, because labyrinthectomized rats readily traversed the magnet. The inner ear is a novel site for magnetic field transduction in mammals, but perturbation of the vestibular apparatus would be consistent with human reports of vertigo and nausea around high strength MRI machines. |
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Authors:
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Thomas A Houpt; Jennifer A Cassell; Christina Riccardi; Megan D DenBleyker; Alison Hood; James C Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-05-31 |
Journal Detail:
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Title: Physiology & behavior Volume: 92 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2008-01-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 741-7 Citation Subset: IM |
Affiliation:
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Department of Biological Science, Biomedical Research Facility 209 MC 4340, The Florida State University, Tallahassee, FL 32306, USA. houpt@neuro.fsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Association Learning / radiation effects* Avoidance Learning / radiation effects* Dose-Response Relationship, Radiation Electromagnetic Fields* Female Perception / radiation effects* Rats Rats, Sprague-Dawley Statistics, Nonparametric Vestibule, Labyrinth / radiation effects* |
| Grant Support | |
ID/Acronym/Agency:
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NIDCD 04607//PHS HHS; R01 DC004607-06/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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