Document Detail


A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy.
MedLine Citation:
PMID:  23047156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stroke is the fourth leading cause of death in the United States and the leading cause of long-term disability. Ischemic stroke, due to an interruption in blood supply, is particularly prevalent; 87% of all strokes are ischemic. Unfortunately, current options for acute treatment are extremely limited and there is a great need for new treatment strategies. This review will discuss evidence that mild sensory stimulation can completely protect the jeopardized brain from an impending stroke in a rodent model. When delivered within the first 2 hours following ischemic onset, this stimulation results in complete protection, including a full reestablishment of cortical function, sensorimotor capabilities, and blood flow. Identical stimulation, however, initiated 3 hours following ischemic onset, results in an increase in damage compared with untreated animals. The protective effect is not specific to a single sensory modality, anesthesia, or age, and increasing evoked cortical activity by increasing stimulation accelerates recovery. Taken together, these findings demonstrate that cortical activity is a critical factor for protection and suggest a new, exciting potential avenue for the development of acute stroke treatment strategies that may produce a noninvasive, drug-free, equipment-free, and side effect-free means of protecting from ischemic stroke.
Authors:
Ron D Frostig; Christopher C Lay; Melissa F Davis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-09
Journal Detail:
Title:  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry     Volume:  19     ISSN:  1089-4098     ISO Abbreviation:  Neuroscientist     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-12-11     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  9504819     Medline TA:  Neuroscientist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-28     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / physiology*
Animals
Brain / blood supply,  physiopathology
Disease Models, Animal
Humans
Outcome Assessment (Health Care)
Physical Stimulation / methods*
Rats
Stroke / diagnosis,  prevention & control*
Time Factors
Treatment Outcome
Vibrissae / innervation,  physiology*
Grant Support
ID/Acronym/Agency:
1T32DC010775-01/DC/NIDCD NIH HHS; NS-055832/NS/NINDS NIH HHS; NS-066001/NS/NINDS NIH HHS; R01 NS055832/NS/NINDS NIH HHS; R01 NS066001/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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