| Rats display a robust bimodal preference profile for sucralose. | |
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MedLine Citation:
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PMID: 21653913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female Sprague-Dawley rats display considerable variability in their preference for the artificial sweetener sucralose over water. While some rats can be classified as sucralose preferrers (SP), as they prefer sucralose across a broad range of concentrations, others can be classified as sucralose avoiders (SA), as they avoid sucralose at concentrations above 0.1 g/L. Here, we expand on a previous report of this phenomenon by demonstrating, in a series of 2-bottle 24-h preference tests involving water and an ascending series of sucralose concentrations, that this variability in sucralose preference is robust across sex, stage of the estrous cycle, and 2 rat strains (Long-Evans and Sprague-Dawley). In a second experiment involving a large sample of rats (n = 50), we established that the ratio of SP to SA is approximately 35-65%. This bimodal behavioral response to sucralose appears to be driven by taste because rats display a similar bimodal licking response to a range of sucralose solutions presented during brief-access tests. Finally, we have shown that sucralose avoidance is extremely robust as 23-h water-deprived SA continue to avoid sucralose in 1-h single-bottle intake tests. Based on their reduced licking responses to sucralose during brief-access (taste driven) tests, and the fact that their distaste for sucralose cannot be overcome by the motivation to rehydrate, we conclude that SA detect a negative taste quality of sucralose that SP are relatively insensitive to. |
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Authors:
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Gregory C Loney; Ann-Marie Torregrossa; James C Smith; Anthony Sclafani; Lisa A Eckel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-08 |
Journal Detail:
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Title: Chemical senses Volume: 36 ISSN: 1464-3553 ISO Abbreviation: Chem. Senses Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-19 Completed Date: 2012-01-06 Revised Date: 2012-04-03 |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: England |
Other Details:
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Languages: eng Pagination: 733-45 Citation Subset: IM |
Affiliation:
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Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Food Preferences* Male Rats / physiology* Rats, Long-Evans Rats, Sprague-Dawley Sex Factors Sucrose / analogs & derivatives*, metabolism Sweetening Agents / metabolism* Taste Taste Perception |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK031135-29/DK/NIDDK NIH HHS; R01 DK073936/DK/NIDDK NIH HHS; T32 DC000044/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sweetening Agents; 56038-13-2/trichlorosucrose; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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