Document Detail


Rationale for ureteral tapering.
MedLine Citation:
PMID:  7147526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With two to three weeks of obstruction, marked ureteral dilatation develops in the presence of relatively low intraluminal pressures. The low pressure and increasing dimensions primarily reflect alterations in intrarenal hemodynamics and the viscoelasticity of the ureteral wall, respectively. Associated with these changes, the ureteral muscle hypertrophies, and this is accompanied by an increase ability to contract, as evidenced by an increase in contractile force and stress. Despite muscle hypertrophy and increased contractility, the dilated ureter is less able to generate the contractile intraluminal pressure waves that are required for urine transport. This paradoxical decrease in intraluminal pressure with increasing contractile force and diameter is explained by the Laplace relationship which also provides a rationale for ureteral tapering. Ureteral tapering by decreasing diameter allows the obstructed ureter's ability to generate contractile forces to be translated into higher contractile intraluminal pressures which provide for more efficient urine transport.
Authors:
R M Weiss; P Biancani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Urology     Volume:  20     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  482-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Hypertrophy
Models, Biological
Muscle Contraction
Muscle, Smooth / pathology
Pressure
Rabbits
Stress, Mechanical
Ureter / pathology,  physiopathology*
Ureteral Obstruction / physiopathology*
Urodynamics*
Grant Support
ID/Acronym/Agency:
R01-AG 00112/AG/NIA NIH HHS; R01-AM-16021/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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