Document Detail


Rationale and study design of dietary intervention in patients polypectomized for tumors of the colorectum.
MedLine Citation:
PMID:  12578906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have implemented a randomized controlled dietary intervention in patients polypectomized for tumors of the colorectum to elucidate potential beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) on the development of colorectal tumors. Those individuals in the experimental group were advised not only to decrease their consumption of fats/oils as a whole and foods supplying n-6 PUFAs but also to increase intake of foods and supplements containing n-3 PUFAs, while those in the comparison group were cautioned to reduce intake of fats/oils as a whole. Patients' compliance/adherence was monitored with a semi-quantitative food frequency questionnaire and by assessment of fatty acid concentrations in plasma, membranes of red blood cells and sigmoid colon samples. As for endpoints to assess tumor suppressive effects of n-3 PUFAs, the number/multiplicity, sizes and incidence rates of colorectal tumors were compared between the experimental and comparison groups after 12 and 24 months of the dietary intervention. On the specified assumption, the number of pairs needed for achieving statistical significance was calculated to be approximately 60-80. A randomized controlled trial is under way to secure enough patients, sustain compliance/adherence and minimize dropouts.
Authors:
Shinkan Tokudome; Yoshifumi Yokoyama; Takeshi Kamiya; Kyoji Seno; Harumi Okuyama; Kiyonori Kuriki; Jinglei Cheng; Takaaki Nakamura; Toshiko Fujii; Hiromitsu Ichikawa; Makoto Itoh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  32     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-11     Completed Date:  2003-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  550-3     Citation Subset:  IM    
Affiliation:
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Japan. tokudome@med.nagoya-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / therapy*
Adenoma / therapy*
Colonic Polyps / surgery*
Colorectal Neoplasms / therapy*
Colorectal Neoplasms, Hereditary Nonpolyposis / therapy
Diet*
Dietary Fats / administration & dosage
Dietary Supplements*
Fatty Acids, Omega-3 / administration & dosage
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / administration & dosage*
Fish Oils / administration & dosage
Humans
Intervention Studies
Research Design
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Fish Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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