Document Detail


Rationale for ibuprofen co-administration with antacids: potential interaction mechanisms affecting drug absorption.
MedLine Citation:
PMID:  18280125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introduction of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo.
Authors:
Jelena Parojcić; Owen I Corrigan
Related Documents :
8887725 - Solidification studies of polyethylene glycols, gelucire 44/14 or their dispersions wit...
6524525 - The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid di...
10944385 - Dissolution kinetics of three-component compressed solid mixtures with largely differen...
19816955 - Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous sba-15 to en...
18604235 - Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced t...
3161705 - Erythema annulare centrifugum: an unusual case due to hydroxychloroquine sulfate.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2008-01-10
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  69     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  640-7     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, University of Belgrade, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antacids / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Chemistry, Pharmaceutical
Drug Combinations
Drug Interactions
Excipients
Humans
Ibuprofen / administration & dosage*
Intestinal Absorption / drug effects*
Solubility
Chemical
Reg. No./Substance:
0/Antacids; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drug Combinations; 0/Excipients; 15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Commentary to the article "Human skin penetration of the major components of Australian tea tre...
Next Document:  6-MSAS-like polyketide synthase genes occur in lichenized ascomycetes.