Document Detail


Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha.
MedLine Citation:
PMID:  20127943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large body of evidence suggests that the platelet-derived growth factor (PDGF) family and associated receptors are potential targets in oncology therapeutic development because of their critical roles in the proliferation and survival of various cancers and in the regulation and growth of the tumor stroma and blood vessels. Several small molecules that nonspecifically target the PDGF signaling axis are in current use or development as anticancer therapies. However, for the majority of these agents, PDGF and its receptors are neither the primary targets nor the principal mediators of anticancer activity. IMC-3G3, a fully human monoclonal antibody of the immunoglobulin G subclass 1, specifically binds to the human PDGF receptor alpha (PDGFRalpha) with high affinity and blocks PDGF ligand binding and PDGFRalpha activation. The results of preclinical studies and the frequent expression of PDGFRalpha in many types of cancer and in cancer-associated stroma support a rationale for the clinical development of IMC-3G3. Currently, IMC-3G3 is being evaluated in early clinical development for patients with several types of solid malignancies.
Authors:
Gaurav D Shah; Nick Loizos; Hagop Youssoufian; Jonathan D Schwartz; Eric K Rowinsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  116     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1018-26     Citation Subset:  AIM; IM    
Copyright Information:
(c) 2010 American Cancer Society.
Affiliation:
ImClone Systems Corporation, 33 ImClone Drive, Branchburg, NJ 08876, USA. gaurav.shah@imclone.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / therapeutic use*
Antineoplastic Agents / therapeutic use*
Drug Delivery Systems
Drug Design
Humans
Immunoglobulin G / therapeutic use
Mice
Neovascularization, Pathologic / drug therapy
Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors*,  immunology,  physiology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/IMC-3G3; 0/Immunoglobulin G; EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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