Document Detail


Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction.
MedLine Citation:
PMID:  10618556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mortality rate from ST-elevation myocardial infarction remains high in elderly patients and in patients who are not eligible for reperfusion therapy. Intravenous magnesium is a promising adjunctive treatment that may reduce reperfusion injury. Several earlier trials demonstrated a mortality rate reduction with magnesium treatment, but one large trial found no benefit.
STUDY DESIGN: Magnesium in Coronaries (MAGIC) is a large, simple trial designed to maximize the potential treatment effect of magnesium. 10, 400 high-risk patients with ST-elevation myocardial infarction will be randomly assigned to early treatment with intravenous magnesium sulfate or matching placebo. The primary end point is death at 30 days. Information on the need for treatment of shock and sustained ventricular arrhythmias will be collected to investigate the mechanisms by which magnesium might exert a beneficial effect.
IMPLICATIONS: If magnesium proves beneficial, its use will provide a simple, cost-effective means to improve survival in this large patient population.
Authors:
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  139     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-27     Completed Date:  2000-01-27     Revised Date:  2013-09-20    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  AIM; IM    
Affiliation:
New England Research Institutes, Inc., Clincal Trial Center, Watertown, MA 02472, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Calcium Channel Blockers / administration & dosage*
Double-Blind Method
Electrocardiography
Humans
Injections, Intravenous
Magnesium Sulfate / administration & dosage*
Myocardial Infarction / drug therapy*,  mortality,  physiopathology
Survival Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 7487-88-9/Magnesium Sulfate
Investigator
Investigator/Affiliation:
E Antman / ; S Feinstein / ; B Gersh / ; B Gibler / ; M Haigney / ; J Hochman / ; L Opie / ; W Rogers / ; K Woods / ; S McKinlay / ; S Hagner / ; M Domanski / ; Y Rosenberg / ; H Cooper / ; J Norman / ; P Mills /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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