| Rationale and design for the SARIS trial; effect of statin on atherosclerosis and vascular remodeling assessed with intravascular sonography. Effect of Statin on Atherosclerosis and vascular Remodeling assessed with Intravascular Sonography. | |
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MedLine Citation:
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PMID: 11800418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The SARIS study (effect of Statin on Atherosclerosis and vascular Remodeling assessed with Intravascular Sonography) is a prospective randomized multicenter trial designed to assess both morphological and functional cardiovascular effects of atorvastatin. METHODS: Participating centers will include 50 patients with normal to mildly elevated cholesterol levels eligible for balloon angioplasty and/or stent placement of the common iliac artery. Patients will be randomized to 1-year treatment with either low-dose (10 mg) or high-dose (80 mg) atorvastatin. The morphological effects of atorvastatin will be studied using intravascular ultrasound (IVUS); the effect of atorvastatin on both plaque volume and vascular remodeling seen at 1-year follow-up will be investigated. The functional cardiovascular effects of atorvastatin will be studied using dobutamine stress echocardiography (DSE); the effect of atorvastatin on myocardial coronary flow reserve at 6-months and 1-year follow-up will be investigated. The aims of the present study are noteworthy in respect that (1) IVUS is the only available technique to sensitively measure the effect of atorvastatin on both intimal hyperplasia and vascular remodeling, and (2) DSE is a non-invasive test to objectively quantify the effect of atorvastatin on the functionality of the coronary artery. |
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Authors:
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T Hagenaars; E J Gussenhoven; D Poldermans; H van Urk; A van der Lugt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 15 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2002-01-21 Completed Date: 2002-05-14 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 339-43 Citation Subset: IM |
Affiliation:
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Department of Experimental Echocardiography, Erasmus Medical Center Rotterdam, The Netherlands. hagenaars@tch.fgg.eur.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Arteriosclerosis / drug therapy*, ultrasonography Cholesterol / analysis Coronary Circulation / drug effects* Echocardiography, Stress / methods Female Heptanoic Acids / therapeutic use* Humans Hyperplasia / drug therapy Male Multicenter Studies as Topic Prospective Studies Pyrroles / therapeutic use* Sensitivity and Specificity Tunica Intima / drug effects*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Pyrroles; 57-88-5/Cholesterol; A0JWA85V8F/atorvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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