| Rationale and design of the NAGOYA HEART Study: comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance. | |
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MedLine Citation:
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PMID: 20409690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inhibitors of the renin angiotensin system are recommended as the first-line medications for diabetic hypertensive patients. However, there is less evidence supporting this recommendation especially among East Asians, a population with a unique distribution of cardiovascular disease compared to the Western population. METHODS AND RESULTS: The NAGOYA HEART Study is a prospective randomized open-label blinded-endpoint study to compare an angiotensin II receptor blocker, valsartan, and a calcium channel blocker, amlodipine, regarding their efficacies on cardiovascular morbidity and mortality in Japanese hypertensive patients with glucose intolerance. Of 1168 eligible patients, we enrolled 1150 patients from October 2004 to January 2009. The participants will be followed for more than a median follow-up period of 3 years. The primary composite endpoint includes myocardial infarction, stroke, coronary revascularization, and admission due to congestive heart failure or sudden cardiac death. Any of these events are adjudicated by an independent committee under blinded information regarding the treatment arm. Secondary endpoints include all-cause mortality, changes in glucose tolerance status, kidney function, left ventricular structure measured by echocardiogram, and incident atrial fibrillation/flutter. The study was registered at ClinicalTrials.gov NCT00129233. CONCLUSION: The NAGOYA HEART Study will provide us with a relevant insight for appropriate treatment of hypertension with glucose intolerance. |
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Authors:
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Kunihiro Matsushita; Takashi Muramatsu; Takahisa Kondo; Kengo Maeda; Satoshi Shintani; Toyoaki Murohara; |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-04-20 |
Journal Detail:
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Title: Journal of cardiology Volume: 56 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00129233 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amlodipine / therapeutic use* Angiotensin II Type 1 Receptor Blockers / therapeutic use* Antihypertensive Agents / therapeutic use* Calcium Channel Blockers / therapeutic use* Diabetes Complications / drug therapy* Humans Hypertension / drug therapy* Middle Aged Prospective Studies Tetrazoles / therapeutic use* Valine / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine; 88150-42-9/Amlodipine |
| Investigator | |
Investigator/Affiliation:
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Toyoaki Murohara / ; Takahisa Kondo / ; Satoshi Shintani / ; Kengo Maeda / ; Kunihiro Matsushita / ; Takashi Muramatsu / ; Masato Watarai / ; Nobuyuki Marui / ; Chiei Takanaka / ; Miyoshi Ohno / ; Toshihiro Obayashi / ; Taizo Kondo / ; Yasunobu Takada / ; Yoshio Iwama / ; Makoto Akahoshi / ; Masato Iida / ; Haruo Hirayama / ; Shizuoka Sone / ; Osamu Ohno / ; Shinji Kaneko / ; Satoshi Ichimiya / ; Tatsuaki Matsubara / ; Kimihiro Komori / ; Manabu Doyu / ; Hideaki Toyoshima / ; Yutaka Oiso / ; Makoto Hirai / ; Toyoaki Murohara / ; Takahisa Kondo / ; Satoshi Shintani / ; Kengo Maeda / ; Kunihiro Matsushita / ; Takashi Muramatsu / ; Kumi Sasaki / ; Emiko Watanabe / ; Yoko Inoue / ; Nobuo Shirahashi / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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