| Rationale for antithrombotic therapy in atrial fibrillation. | |
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MedLine Citation:
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PMID: 1557005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antithrombotic therapy is clearly indicated in patients with atrial fibrillation who have associated factors that put them at significant risk for thromboembolism This does not include subjects with lone atrial fibrillation who are less than 60 years of age. High-risk patients include those with valvular heart disease, recent congestive heart failure, severe left ventricular dysfunction by echocardiography, prior thromboembolism, demonstration of a cardiac thrombus by echocardiography, and thyrotoxicosis. Anticoagulant therapy appears to be the most efficacious means of preventing thromboembolism in atrial fibrillation. Potential bleeding complications with sodium warfarin mandate judicious selection of patients for long-term anticoagulant therapy. The risk of anticoagulant therapy certainly appears justified in subjects who are at high risk for thromboembolism and can be monitored with a reasonable degree of safety. Aspirin therapy is a reasonable alternative for those subjects at relatively lower risk of thromboembolism, especially subjects who are not suitable candidates for anticoagulation. The efficacy of aspirin has not been established in patients with atrial fibrillation who are greater than 75 years of age. |
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Authors:
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R E Kelley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurologic clinics Volume: 10 ISSN: 0733-8619 ISO Abbreviation: Neurol Clin Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-05-06 Completed Date: 1992-05-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 233-49 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Miami School of Medicine, Florida. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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administration & dosage Atrial Fibrillation / drug therapy* Fibrinolytic Agents / administration & dosage* Follow-Up Studies Humans Intracranial Embolism and Thrombosis / etiology, prevention & control* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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