Document Detail


Rationale and Design of an Observational Study to Determine the Effects of Cholecalciferol on Hypertension, Proteinuria and Urinary MCP-1 in ADPKD.
MedLine Citation:
PMID:  23971693     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of kidney failure in the world. Currently there are no treatments to prevent kidney due to ADPKD. Vitamin D is traditionally known for its role in maintaining calcium balance and normal bone health, but it is being increasingly being recognised for a number of other important physiological functions, including reducing blood pressure and proteinuria as well as kidney inflammation andfibrosis. Vitamin D deficiency is associated with proteinuria, increased mortality and may mediate the progression to kidney failure. Recent data from an Australian cohort study (AusDiab) reveals that vitamin D deficiency and insufficiency are common conditions, affecting 26.6% and 42.1% of the Australian community respectively. Preclinical studies from our laboratory have identified that vitamin D deficiency exacerbates proteinuria and hypertension in experimental PKD, and that this is reversed by treatment with vitamin D receptor agonist. In this manuscript, we report the rational and design of an open-label observational study of humans with ADPKD (eGFR>30 ml/min/1.73m2). All subjects will undergo screening for vitamin D levels at the beginning of study, and those that are found to be either deficient (<50 nmol/L) or insufficient (<75 nmol/L) will be repleted with oral cholecalciferol for 6 months. We predict that cholecalciferol will attenuate hypertension, proteinuria and reduce the urinary excretion of a biomarker, monocyte chemoattractant protein-1 (MCP-1, a surrogate inflammatory marker of progression in ADPKD). This study will provide evidence as to whether a simple intervention such as vitamin D repletion, in either deficient or insufficient states, is a treatment to prevent kidney failure in ADPKD.
Authors:
Gopala K Rangan; David C Harris
Related Documents :
8479243 - The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo.
3790213 - Cigarette smoking blocks caffeine-induced arousal.
8335583 - Segmental vascular pressures in lung embolism.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reviews     Volume:  9     ISSN:  1875-6506     ISO Abbreviation:  Curr Hypertens Rev     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-08-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239891     Medline TA:  Curr Hypertens Rev     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Affiliation:
Centre for Transplant and Renal Research, Level 2, Clinical Sciences Block, Westmead Hospital, Cnr Bridge and Darcy Roads, Westmead, NSW, Australia 2145. g.rangan@sydney.edu.au.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Renoprotective Effects of the L-/T-type Calcium Channel Blocker Benidipine in Patients with Hyperten...
Next Document:  Interactions between the sympathetic nervous system and Angiotensin system in renovascular hypertens...