Document Detail


Rationale and design of the OPTION study: optimal antitachycardia therapy in ICD patients without pacing indications.
MedLine Citation:
PMID:  20487351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Implantable cardioverter-defibrillators (ICDs) represent the treatment of choice for primary and secondary prevention of sudden cardiac death but ICD therapy is also plagued by inappropriate shocks due to supraventricular tachyarrhythmias. Dual-chamber (DC) ICDs are considered to exhibit an enhanced discrimination performance in comparison to single-chamber (SC) ICDs, which results in reduction of inappropriate detections in a short- to mid-term follow-up. Comparative data on long-term follow-up and especially on inappropriate shocks are limited.
METHODS: The aim of the OPTION study is to assess whether an optimized treatment with DC ICDs improves patient outcome and decreases the rate of inappropriate shocks in comparison to SC ICDs. DC ICD therapy optimization is achieved by optimal customizing of antitachycardia therapy parameters, activation of discrimination algorithms, antitachycardia pacing in the slow ventricular tachycardia zone, and avoidance of right ventricular pacing with the SafeR algorithm mode. The OPTION study, a prospective, multicenter, randomized, single-blinded, parallel study, will randomize 450 patients on a 1:1 allocation to either an SC arm with backup pacing at VVI 40 beats per minute (bpm) or to the DC arm with SafeR pacing at 60 bpm. Patients will be followed for 27 months. Primary outcome measure is the time to first occurrence of inappropriate shock and a combined endpoint of cardiovascular morbidity and all-cause mortality.
CONCLUSION: The study will evaluate the relative performance of DC in comparison to SC ICDs in terms of inappropriate shock reduction and patient outcome.
Authors:
Christof Kolb; Stylianos Tzeis; Marcio Sturmer; Dominique Babuty; Jörg O Schwab; Giuseppe Mantovani; Sabine Janko; Ezio Aimé; Rolf Ocklenburg; Peter Sick
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  33     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-02-28     Revised Date:  2011-04-20    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1141-8     Citation Subset:  IM    
Copyright Information:
©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc.
Affiliation:
Deutsches Herzzentrum und 1, Faculty of Medicine, Technische Universität München, Munich, Germany. kolb@dhm.mhn.de
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00729703
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / therapy*
Cardiac Pacing, Artificial
Clinical Protocols
Death, Sudden, Cardiac / prevention & control
Defibrillators, Implantable*
Humans
Patient Selection
Research Design
Single-Blind Method
Tachycardia / therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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