Document Detail

Rationale for ACE inhibition as an anti-ischaemic therapy.
MedLine Citation:
PMID:  9717054     Owner:  NLM     Status:  MEDLINE    
Research has established endothelial dysfunction as a pathophysiological mechanism underlying many cardiovascular disease processes. Tissue angiotensin-converting enzyme (ACE) plays a central role in regulating processes that contribute to endothelial function and cardiovascular disease. A number of large clinical studies have demonstrated conclusively the beneficial effects of ACE inhibition in patients with myocardial ischaemia and left ventricular dysfunction, including a significant reduction in the risk of recurrent myocardial infarction. Mechanistic findings from these studies indicated that the beneficial effects of ACE inhibition would extend to patients with preserved left ventricular function. Available results suggest that ACE inhibition with quinapril improves endothelial function in large and small vessels in patients with coronary artery disease and preserved left ventricular function. Quinapril also inhibits progression of coronary atherosclerosis in patients with high levels of low-density lipoprotein cholesterol (> or = 130 mg.dl-1) and reverses the toxic effects of smoking on endothelial function. Endothelial dysfunction also may be an important mechanism in episodes of angina and silent ischaemia. The central role of tissue ACE in endothelial function suggests that ACE inhibition has antiischaemic effects. A study in progress, the QUinapril Antiischaemia and Symptoms of Angina Reduction trial, addresses shortcomings in earlier studies of ACE inhibition for ischaemia and is expected to define the role of quinapril in ischaemia.
C J Pepine
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  19 Suppl G     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  G34-40     Citation Subset:  IM    
University of Florida College of Medicine, Gainesville 32610-0277, USA.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use*
Cholesterol, LDL / blood
Coronary Artery Disease / drug therapy,  mortality
Coronary Disease / drug therapy*,  mortality
Endothelium, Vascular / drug effects
Isoquinolines / adverse effects,  therapeutic use*
Myocardial Ischemia / drug therapy*,  mortality
Randomized Controlled Trials as Topic
Survival Rate
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Cholesterol, LDL; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril

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