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Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions.
MedLine Citation:
PMID:  24720969     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although Zn(2+) ions are involved in large numbers of physiopathological processes, non-invasive detection of Zn(2+) ions in opaque biological samples remains a huge challenge. Here, we developed a novel zinc-responsive hyperpolarized (HP) (129)Xe-based NMR molecular sensor. This HP (129)Xe-based NMR molecular sensor was synthesized by attaching 2-(diphenylphosphino) benzenamine as ligand for zinc ions to the xenon-binding supramolecular cage, cryptophane. The (129)Xe NMR spectroscopy of such molecular sensor was shifted up to 6.4ppm in the presence of Zn(2+) ions, which was nearly four times larger than that of the reported similar sensor. The application of the sensor would benefit low concentration detection by using indirect NMR/MRI method. The response exhibited high sensitivity and selectivity as discriminated from other six potentially competing metal ions. The application of this sensor in the analysis of zinc ions in the rat serum samples was also evaluated. The strategy is generally applicable in developing sensitive and selective sensors for quantitative determination of zinc ions.
Authors:
Ji Zhang; Weiping Jiang; Qing Luo; Xiaoxiao Zhang; Qianni Guo; Maili Liu; Xin Zhou
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Publication Detail:
Type:  Journal Article     Date:  2014-01-31
Journal Detail:
Title:  Talanta     Volume:  122     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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