Document Detail

Rational design of highly selective spleen tyrosine kinase inhibitors.
MedLine Citation:
PMID:  23151054     Owner:  NLM     Status:  Publisher    
A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed Phase II clinical trials, also exhibits some undesirable side effects. More selective Syk inhibitors could offer safer, alternative treatments. Through a systematic evaluation of the kinome, we identified Pro455 and Asn457 in the Syk ATP binding site as a rare combination among sequence aligned kinases and hypothesized that optimizing the interaction between them and a Syk inhibitor molecule would impart high selectivity for Syk over other kinases. We report the structure-guided identification of three series of selective spleen tyrosine kinase inhibitors that support our hypothesis, and offer useful guidance to other researchers in the field.
Matthew Charles Lucas; David Michael Goldstein; Johannes Cornelius Hermann; Andreas Kuglstatter; Cheng Liao; Wenjian Liu; Fernando Padilla; Michelle Slade; Jutta Wanner; Wenwei Xie; Xiaohu Zhang; Kin-Chun Luk
Related Documents :
20816664 - Testosterone-induced hypertrophy of l6 myoblasts is dependent upon erk and mtor.
23305904 - Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-...
24492844 - B-raf and its novel negative regulator reticulocalbin 1(rcn1) modulate cardiomyocyte hy...
23418854 - Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based...
9271314 - Phosphatase inhibitors potentiate 4-hydroxynonenal-induced phospholipase d activation i...
20427464 - A dibasic amino acid pair conserved in the activation loop directs plasma membrane loca...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Identifying specific non-attending groups in breast cancer screening - population-based registry stu...
Next Document:  Normal values of aortic dimensions, distensibility, and pulse wave velocity in children and young ad...